P080 State-dependency of nocturnal swallowing in healthy adults: Incidence, motor function and coordination with breathing

Abstract Introduction Swallowing involves a complex motor pattern and coordination with breathing other oro-motor behaviors. Sleep has major depressive effect on many of the neuronal pools that facilitate swallowing, particularly upper airway muscles. This study examines state-depedence swallow program breathing. Methods Adult subjects recruited from community undertook an overnight sleep laboratory study. Subjects were instrumented to monitor (EEG), (nasal mask, pneumotach), swallowing / valving events (epiglottic pressure, submental EMG) pharyngeal muscle activity (peroral genioglosuss EMG electrodes).We report preliminary findings (N=5; 2 female; age: 23-57 yrs) ongoing Data reported mean ± SD. Results Nocturnal occurred intermittently thoughout night, majority triggered during arousal (43-98% all nocturnal swallows). Pharyngeal pressure was 147±44 cmH2O quiet wake, 137±25 sleep, 78 23 in stable (p=0.02, RM-ANOVA). Swallows generated brief, near-maximal burst genioglossus wake (90 %, N=2) (107 24 %). In 34 1 %. wakefulness expiration, vast bracketed by expiration (Ex/Ex). or phases respiratory cycle. Conclusions elicited generate ballistic pressures equivalent state. contrast, produces markedly attenuated pressure.